One by One: Target COVID-19 is a pan-African, coalition-driven communications and advocacy campaign created by The Access Challenge, the African Union, the Africa CDC and WHO AFRO. Since April 2020, the Coalition has supported the Africa CDC in its continental COVID-19 response by engaging catalytic partnerships and mobilizing influencers, called AfricaCOVIDChampions, from all sectors to use their viral platforms to combat COVID-related misinformation and promote critical prevention behaviors via mass media campaigns.